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Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP
BACKGROUND The Rnd proteins Rnd1, Rnd2, and Rnd3 (RhoE) comprise a unique branch of Rho-family G-proteins that lack intrinsic GTPase activity and consequently remain constitutively "active." Prior studies have suggested that Rnd proteins play pivotal roles in cell regulation by counteracting the biological functions of the RhoA GTPase, but the molecular basis for this antagonism is unknown. Pos...
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ژورنال
عنوان ژورنال: Behavior Research Methods, Instruments, & Computers
سال: 1988
ISSN: 0743-3808,1532-5970
DOI: 10.3758/bf03203835